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is an inhibitor of SETD8 with cellular activity
2-dichlorobenzene)
22)/b19-11+
32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6
1418033-25-6
IDH2-C100 - IHD2 Inhibitor. CAS# 1446506-78-0 0331 is an inhibitor of SETD8IDH2 C100, CAS No. 1446506 78 0, is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431. It can inhibit the enzymatic activity of IDH2 R140Q and R172K in vitro with an IC50 < 0. 1 M. It has IC50 < 0. 1 M in U87MG pLVX IDH2 R140Q neo cell based assay. It is an analog of clinical IDH2 inhibitor AG 221 by Thomson Reuters Integrity analysis. Product information CAS Number: 1446506 78 0 Molecular Weight:
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